Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca -sensitive K channels
نویسندگان
چکیده
André Heinen, Mohammed Aldakkak, David F. Stowe, Samhita S. Rhodes, Matthias L. Riess, Srinivasan G. Varadarajan, and Amadou K. S. Camara Anesthesiology Research Laboratories, Departments of Anesthesiology and Physiology and Cardiovascular Research Center, Medical College of Wisconsin, Zablocki Department of Veterans Affairs Medical Center Research Service, and Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin; and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, Amsterdam, the Netherlands
منابع مشابه
Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels.
Mitochondria generate reactive oxygen species (ROS) dependent on substrate conditions, O(2) concentration, redox state, and activity of the mitochondrial complexes. It is well known that the FADH(2)-linked substrate succinate induces reverse electron flow to complex I of the electron transport chain and that this process generates superoxide (O(2)(*-)); these effects are blocked by the complex ...
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تاریخ انتشار 2007